Animal models are crucial for Leber's congenital claustrophobia (LCA) research and treatment development. Our company provides customized animal modeling services for LCA to help our clients elucidate genetic defects underlying retinal disease, understand disease mechanisms, and provide tools for translational research and development of gene-based therapies to interfere with disease progression. With over 20 years of experience in animal modeling and a team of experts with extensive knowledge and expertise, we are confident in our ability to provide high-quality services for LCA research.

Background

LCA is a rare genetic retinal degenerative disease that affects the eyes. In addition to early vision loss, the disease is associated with other ocular abnormalities, including roving eye movements, deep-set eyes, and sensitivity to bright light. LCA is caused by mutations in one of several genes involved in the development and function of the retina, the light-sensitive tissue at the back of the eye. Of these, LCA caused by mutations in the RPE65 gene accounts for ~20% of the disease in the human population and is an ideal target for developing treatments. Although there is no cure for LCA, preclinical studies being conducted in multiple LCA animal models may lead to improved treatments and possibly a cure in the future.

Learn more：animal models of leber's congenital amaurosis